P009 Molecular Abnormalities In Paediatric Barrett’s Oesopha- gus: Can We Test For Potential of Neoplastic Progression?

Gastroesophageal Reflux Disease: Molecular Predictors in Neoplastic Progression of Barrett’s Esophagus

Undergo Clonal Expansion in Barrett's Metaplastic Epithelium Lesions Are Common, Early Abnormalities

Barrett’s esophagus (BE) is the only known precursor to esophageal adenocarcinoma, a cancer of which the incidence has been increasing at an alarming rate in Western countries. p16 lesions occur frequently in esophageal adenocarcinomas but their role in neoplastic progression is not well understood. We detected 9p21 loss of heterozygosity, p16 CpG island methylation, and p16 mutations in biopsi...

Effects of valproic acid and pioglitazone on cell cycle progression and proliferation of T-cell acute lymphoblastic leukemia Jurkat cells

Objective(s): T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignant tumor. Administration of chemical compounds influencing apoptosis and T cell development has been discussed as promising novel therapeutic strategies. Valproic acid (VPA) as a recently emerged anti-neoplastic histone deacetylase (HDAC) inhibitor and pioglitazone (PGZ) as a high-affinity peroxisome p...

Bed Utilisation in an Irish Regional Paediatric Unit – A Cross-Sectional Study Using the Paediatric Appropriateness Evaluation Protocol (PAEP)

Background Increasing demand for limited healthcare resources raises questions about appropriate use of inpatient beds. In the first paediatric bed utilisation study at a regional university centre in Ireland, we conducted a cross-sectional study to audit the utilisation of inpatient beds at the Regional Paediatric Unit (RPU) in University Hospital Limerick (UHL), Limerick, Ireland and also exa...

Controversies in the current therapy of carcinoma of the esophagus.

Although esophageal carcinoma is a relatively uncommon malignancy, its prevalence is increasing by approximately 10% per year, which is faster than any other malignancy. This increase is largely secondary to the well-established association between gastroesophageal reflux disease, Barrett’s esophagus, and esophageal adenocarcinoma. In most Western countries, esophageal carcinoma has undergone a...